If you've arrived at this article because you got an error message that PowerPoint can't read a file or that the presentation cannot be opened, it's likely that Microsoft 365 has blocked the file for security reasons. You can unblock the file so it can be opened:
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Open Windows File Explorer (Open Start in Windows and type File Explorer.)
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Locate the problematic file on your computer.
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Right-click the file and select Properties.
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In the Properties dialog box, look for an Unblock button near the bottom right. If it exists, click Unblock, then click Apply, and then click OK to dismiss the dialog box.
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Now, attempt to open the presentation again. Right-click the file in File Explorer and select Open.
Still having trouble?
If you're having a problem with PowerPoint that's not resolved here, please contact us for technical support.
For a discussion about why Microsoft 365 blocks files, read Block or unblock external content in Microsoft 365 documents.